Synthesis of rotaxanes with triphenylphosphine as a stopper group

Htoo Shee

Faculty: Vijaykumar Ramalingam

Mechanically Interlocked molecules are perfect combination of covalent and mechanical bond along with a uniquely dynamic feature i.e., restricted molecular motion within in this molecule. One such category of the interlocked molecules is rotaxane. They are mechanically interlocked that consists of a linear molecular species and a cyclic molecular species which is bonded together in a threaded by a noncovalent bond. Dynamic property comes from the fact that the macrocyclic ring inside can move freely between the one stopper to another since it is not covalently bonded to the rod.

This movement can be controlled by changing the functionality and polarity of the end groups, ring, and the rod. In this presentation we focus on the synthesis of Rotaxane, using 1,6 dibromohexane linear rod with triphenylphosphine as a stopper group. We use a microwave reactor for this synthesis.

A macrocyclic species, such as beta-cyclodextrin, crown ether, and Cucurbit[6]uril will be used as the moving molecule and the dibromohexane was used as the linear thread and triphenylphosphine as stopper group to synthesis rotaxane.